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Journal of Molecular Cell Biology Advance Access published online on October 12, 2009
Journal of Molecular Cell Biology, doi:10.1093/jmcb/mjp035
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved

The Engineering of Brown Fat

Mark Christian and Malcolm G. Parker*

Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London W12 0NN, UK

* Correspondence to: Malcolm G. Parker, E-mail: m.parker{at}imperial.ac.uk


  Abstract

The developmental origins of brown adipose tissue and white adipose tissue are distinct, with brown adipocytes being derived from muscle precursors. PR domain containing 16, together with C/EBPβ, forms a lineage-switching transcriptional complex which promotes brown fat differentiation and suppresses muscle cell differentiation.


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