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Journal of Molecular Cell Biology Advance Access published online on October 16, 2009
Journal of Molecular Cell Biology, doi:10.1093/jmcb/mjp034
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved

Type I and Type II Pathways of Fas-mediated Apoptosis Are Differentially Controlled by XIAP

Zhenyue Hao* and Tak W. Mak*

The Campbell Family Cancer Research Institute, University Health Network, Toronto, ON, Canada

* Correspondence to: Zhenyue Hao, E-mail: zyhao{at}uhnres.utoronto.ca; Tak W. Mak, E-mail: tmak{at}uhnres.utoronto.ca


  Abstract

The mechanism by which Fas activates the apoptotic pathway differs in so-called type I and type II cells. X chromosome-linked inhibitor of apoptosis protein has now been revealed as an important molecule that is differentially regulated in type I vs. type II cells.


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