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Journal of Molecular Cell Biology Advance Access published online on October 4, 2009
Journal of Molecular Cell Biology, doi:10.1093/jmcb/mjp033
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.

Rapamycin: The Cure for all that Ails

Paul Hasty*

Department of Molecular Medicine/Institute of Biotechnology, The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245-3207, USA

* Correspondence to: Paul Hasty, Tel: +1-210-567-7278; Fax: +1-210-567-7277; E-mail: hastye{at}uthscsa.edu


  Abstract

Target of rapamycin (TOR) signaling stimulates cell growth by regulating protein synthesis in response to a variety of stimuli in a wide range of species and is inhibited by rapamycin, a naturally occurring antifungal compound produced by bacteria and discovered on Easter Island or in the local vernacular, Rapa Nui (rapamycin's namesake). Recently, rapamycin was shown to extend life span for mice, even when administered late in life, suggesting that inhibiting the mammalian TOR pathway may improve health span for people.


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