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Journal of Molecular Cell Biology Advance Access published online on September 30, 2009
Journal of Molecular Cell Biology, doi:10.1093/jmcb/mjp032
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.

An Expanding Job Description for Bcl6

Enguang Bi and B. Hilda Ye*

Department of Cell Biology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Ave, Bronx, NY 10461, USA

* Correspondence to: B. Hilda Ye, E-mail: hilda.ye{at}einstein.yu.edu


  Abstract

B cell lymphoma/leukemia gene 6 (Bcl6) is well known as a master regulator of germinal center (GC) B cell differentiation. Now, three new publications demonstrate that Bcl6 also plays a second role in GC response, in that it is both required and sufficient to drive the differentiation of T follicular helper cells.


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