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Journal of Molecular Cell Biology Advance Access published online on October 14, 2009
Journal of Molecular Cell Biology, doi:10.1093/jmcb/mjp030
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.

Shifting in Balance Between Osteogenesis and Adipogenesis Substantially Influences Hematopoiesis

Ryohichi Sugimura1 and Linheng Li1,2,*

1 Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110 USA
2 Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS 66160, USA

* Correspondence to: Linheng Li, E-mail: lil{at}stowers.org


  Abstract

Adipocytes have been viewed as a space-filler in bone marrow for a long time. However, a recent study (Naveiras et al., 2009. Nature 460, 259–263) shows that adipocytes are microenvironmental components that suppress hematopoiesis under homeostatic and especially stressed conditions.


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