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Journal of Molecular Cell Biology Advance Access first published online on October 8, 2009
This version published online on October 21, 2009
Journal of Molecular Cell Biology, doi:10.1093/jmcb/mjp029
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved

Direct Activation of Protein Kinases by Ubiquitin

Rebecca Baker and Sankar Ghosh*

Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA

* Correspondence to: Sankar Ghosh, E-mail: sg2715{at}columbia.edu


  Abstract

The inhibitor of kB kinase (IKK) complex, a critical positive regulator of nuclear factor {kappa}B (NF-{kappa}B) signaling and immune function, can be activated in vitro by polyubiquitin chains. The modification of signaling intermediates by polyubiquitin and their association with ubiquitin-binding domain-containing proteins within multimolecular signaling complexes therefore represent a potential mechanism for activation of IKK and NF-{kappa}B in vivo.

The original published version of this paper was incorrect as there was a typographical error in the abstract. Oxford Journals apologise for this error.


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