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Journal of Molecular Cell Biology Advance Access published online on September 30, 2009

Journal of Molecular Cell Biology, doi:10.1093/jmcb/mjp027
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.

Embryonic vs. Adult Myogenesis: Challenging the ‘Regeneration Recapitulates Development’ Paradigm

John Wang and Irina Conboy*

Department of Bioengineering, University of California, Berkeley, 174 Stanley Hall, Berkeley, CA 94720-1762, USA

* Correspondence to: Irina Conboy, E-mail: iconboy{at}berkeley.edu


   Abstract

A popular theory in the stem cell field is that ‘regeneration recapitulates development’, or that adult stem cells function similarly to embryonic ones. In a recent Nature article, Lepper et al. questioned this approach, highlighting the differences in requirements for Pax7 during myogenesis for embryonic, juvenile and adult muscle.


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