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Journal of Molecular Cell Biology Advance Access published online on September 25, 2009
Journal of Molecular Cell Biology, doi:10.1093/jmcb/mjp022
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.

Cholesterol Worships a New Idol

Ira G. Schulman*

Center for Molecular Design and Department of Pharmacology, University of Virginia Health System, Charlottesville, VA 22908, USA

* Correspondence to: Ira G. Schulman, Tel: +1 434 924 5682; Fax: +1 434 982 3878; E-mail: igs4c{at}virginia.edu


  Abstract

The growing worldwide epidemic of cardiovascular disease suggests that new therapeutic strategies are needed to complement statins in the lowering of cholesterol levels. In a recent paper in Science, Tontonoz and colleagues have identified Idol as a protein that can control cholesterol levels by regulating the stability of the low-density lipoprotein receptor; inhibiting the activity of Idol could provide novel approaches for the treatment of cardiovascular disease.


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