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Journal of Molecular Cell Biology Advance Access published online on October 1, 2009
Journal of Molecular Cell Biology, doi:10.1093/jmcb/mjp021
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Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved

A Little ‘Help’ from IL-21 During Persistent Viral Infection

Dorian B. McGavern*

National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, MD 20892, USA

* Correspondence to: Dorian B. McGavern, Tel: +1 301 443 7949; E-mail: mcgavernd{at}mail.nih.gov


  Abstract

Anti-viral CD4+ T cells are required to orchestrate and sustain the activities of the adaptive immune system during a persistent viral infection. Three recent studies suggest that CD4+ T cells accomplish this in part through the release of IL-21.


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