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Journal of Molecular Cell Biology Advance Access published online on August 13, 2009
Journal of Molecular Cell Biology, doi:10.1093/jmcb/mjp015
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.

Macrophage Metalloelastase: Stretching Therapeutic Opportunities

Jeannie Q. He and Menno van Lookeren Campagne*

Department of Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA

* Correspondence to: Menno van Lookeren Campagne, E-mail: menno{at}gene.com


  Abstract

While tissue macrophages are at the first line of microbial host defense, they are also convenient hideouts for pathogens escaping immune attack. Houghton et al. discovered that alveolar macrophage mobilizes macrophage metalloelastase to destroy bacteria present inside the cell.


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