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Journal of Molecular Cell Biology Advance Access published online on August 14, 2009
Journal of Molecular Cell Biology, doi:10.1093/jmcb/mjp014
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.

Cohesin: A Multi-purpose Chromatin Glue

Laura A. Díaz-Martínez and Hongtao Yu*

Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

* Correspondence to: Hongtao Yu, E-mail: hongtao.yu{at}utsouthwestern.edu


  Abstract

Long thought to be the glue responsible for holding sister chromatids together, cohesin has been found to be stickier than previously thought. Recent discoveries point to cohesin having a role in transcription regulation by mediating long-distance intra-chromosomal interactions.


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