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Journal of Molecular Cell Biology Advance Access published online on August 25, 2009
Journal of Molecular Cell Biology, doi:10.1093/jmcb/mjp012
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.

Dynamic Balancing: DEPTOR Tips the Scales

Christopher G. Proud*

School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK

* Correspondence to: Christopher G. Proud, E-mail: c.g.proud{at}soton.ac.uk


  Abstract

The mammalian target of rapamycin, mTOR, is a key node in cellular regulation: its dysregulation is important in a number of disease states, including various cancers. A recent study identifies a new partner and regulator of mTOR, which can alter the balance of signaling downstream of mTOR and appears to be important in certain cancers, such as multiple myelomas.


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