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Journal of Molecular Cell Biology Advance Access originally published online on August 30, 2009
Journal of Molecular Cell Biology 2009 1(2):64-65; doi:10.1093/jmcb/mjp013
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.

When Shigella Tells the Cell to Hang On

Guy Tran Van Nhieu* and Julie Guignot

Inserm U971, Unité de Communications Intercellulaires et Infections Microbiennes, Collège de France, 11, Place Marcelin Berthelot, 75005 Paris Cedex, France

* Correspondence to: Guy Tran Van Nhieu, E-mail: guy.tran-van-nhieu{at}college-de-france.fr


  Abstract

OspE, a Shigella type III effector binds to integrin-like kinase and enhances cell adhesion to better disseminate and colonize the intestinal epithelium. Because of the existence of OspE orthologues in other enteropathogens such as enteropathogenic Escherichia coli or Salmonella sp., maintenance of cell adhesion appears as a widespread strategy for bacteria that interact with the intestinal epithelium.


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