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Journal of Molecular Cell Biology Advance Access originally published online on August 13, 2009
Journal of Molecular Cell Biology 2009 1(1):8-10; doi:10.1093/jmcb/mjp007
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.

RIP Kinases Initiate Programmed Necrosis

Lorenzo Galluzzi1,2,3, Oliver Kepp1,2,3 and Guido Kroemer1,2,3,*

1 INSERM, U848, F-94805 Villejuif, France
2 Institut Gustave Roussy, F-94805 Villejuif, France
3 Université Paris-Sud/Paris XI, F-94270 Le Kremlin Bicêtre, France

* Correspondence to: Guido Kroemer, Tel: +33-1-4211-6046; Fax: +33-1-4211-6047; E-mail: kroemer{at}orange.fr


  Abstract

Some lethal stimuli can induce either apoptosis or necrosis, depending on the cell type and/or experimental setting. Until recently, the molecular bases of this phenomenon were largely unknown. Now, two members of the receptor-interacting serine-threonine kinase (RIP) family, RIP1 and RIP3, have been demonstrated to control the switch between apoptotic and necrotic cell death. Some mechanistic details, however, remain controversial.


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