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Journal of Molecular Cell Biology Advance Access originally published online on July 24, 2009
Journal of Molecular Cell Biology 2009 1(1):3-5; doi:10.1093/jmcb/mjp005
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.

From Breast to the Brain: Unraveling the Puzzle of Metastasis Organotropism

Guohong Hu1, Yibin Kang1,* and Xiao-Fan Wang2,*

1 Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
2 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA

* Correspondence to: Yibin Kang, E-mail: ykang{at}princeton.edu; Xiao-Fan Wang, E-mail: wang0011{at}mc.duke.edu


  Abstract

Metastatic colonization of different target organs is a highly selective process that depends on specialized properties of tumor cells. In a recent Nature paper, Massagué and colleagues built on their earlier success in functional genomic analysis of breast cancer metastasis to bone and lung and reported the identification of breast cancer brain metastasis genes, highlighting the importance of the stromal environment in the development of organ-specific metastasis.


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