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Journal of Molecular Cell Biology Advance Access originally published online on August 11, 2009
Journal of Molecular Cell Biology 2009 1(1):11-12; doi:10.1093/jmcb/mjp008
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© The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.

A Little Bit of Sugar Makes Polycomb Better

Yuri B. Schwartz* and Vincenzo Pirrotta*

Department of Molecular Biology and Biochemistry, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA

* Correspondence to: Yuri B. Schwartz, Tel: +1 732 445 6896, E-mail: schwartz{at}biology.rutgers.edu; Vincenzo Pirrotta, Tel: +1 732 444 2446, E-mail: pirrotta{at}biology.rutgers.edu


  Abstract

Transcriptional repression by Polycomb group (PcG) proteins is now sweetened by the discovery of the essential role of O-GlcNAc glycosylation in the process. PcG protein polyhomeotic may be the key target, but alternative or additional functions including repression of transcription through glycosylation of the C-terminal domain of RNA polymerase II are also possible.


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